Drug-naïve patients with schizophrenia exhibited increased TLR4 mRNA levels and unaltered TLR3 mRNA levels in peripheral blood mononuclear cells (PBMC), alongside elevated TLR4 and TLR8 mRNA levels and reduced TLR3 mRNA levels in white blood cells compared to healthy controls [180,181]. This evidence concerns the gene TLR4 and schizophrenia.