ERBIN and Anxiety: Interestingly, evidence for the involvement of PV+ interneurons in anxiety emerged from a mouse model of mutant Erbin (i.e., a protein expressed in cortical and hippocampal PV+ interneurons regulating fast excitatory synaptic transmission) [354], with inhibition of PV+ cells resulting in anxiogenic effects and reduced excitatory postsynaptic responses in the amygdala [355]).