However, Gajecki et al. [37], in a recent cross-sectional study, found a concentration of L-arg in the erythrocytes of patients in the early stages of T2DM similar to healthy controls, and our earlier cross-sectional data [18] suggested that the L-arg pool from RBCs is not yet depleted in patients with T2DM at the initial clinical onset. The gene discussed is ARHGEF12; the disease is type 2 diabetes mellitus.