On the other hand, there are also patients without a history of insulin resistance that debut with insulin treatment-resistant hyperglycemia at different ages (which can orient us towards a diagnosis of MODY) [16] and patients that display a milder autoimmune process, slower ß-cell failure, and insulin independence for 6 to 12 months after diagnosis (which orient us towards a diagnosis of LADA) [17]. This evidence concerns the gene INS and Insulin resistance.