Humoral aberrations and paraneoplastic phenomena, such as impaired glucose metabolism in skeletal muscle and insulin secretory capacity, have also been implicated in the development of pancreatogenic diabetes resulting from PDAC [24,85], and a recent study suggesting that PDAC-associated T3cDM is clinically distinguishable compared to patients having conventional T2DM [24]. The gene discussed is INS; the disease is diabetes mellitus.