A systematic review of studies assessing co-existence of IgE-mediated allergy/sensitization and CD [6] revealed two original articles that ruled out [15,16] and only four original articles that suggested the possibility of allergy and CD co-occurrence [8,9,10,11], with a vast majority of authors assessing the co-occurrence of CD and sensitization to food allergens. The gene discussed is IGHE; the disease is allergic disease.