Tumor cells were positive for glial fibrillary acidic protein (GFAP; Figure 4B) and microtubule-associated protein 2 (MAP2); a “dot-like” pattern of epithelial membrane antigen (EMA) was focally observed, and a strong nuclear expression of H3K27M mutant protein was found (Figure 4C), while H3K27-3me expression was lost in tumor cells (Figure 4D). The gene discussed is MAP2; the disease is neoplasm.