INS and hyperinsulinism: Alternatively, the relatively underrecognized perinatal stress-induced hyperinsulinism is a prolonged form of non-genetic hyperinsulinemic hypoglycemia associated with perinatal stress (e.g., perinatal depression, small for gestational age, prematurity, and preeclampsia), characterized by the requirement for a high glucose infusion rate, high responsivity to diazoxide (a drug that suppresses insulin secretion via the activation of membrane KATP channels), and eventual resolution within weeks to months after birth, confirmed by a safety fast [16,17].