As such, associated with old age, are: increased ACE2 receptor expression, immune dysregulation (resulting also from sex steroids and growth hormone decrease), gut microbiota changes (contributing to the cytokine storm), mitochondrial dysfunction and oxidative stress in immune cells and pneumocytes—associated with senescence, life-style associated factors (compromised physical activity, nutrition) and aging-associated illnesses (especially CVS, diabetes mellitus) [46]. This evidence concerns the gene GH1 and diabetes mellitus.