In conclusion, due to the differences between the results of our meta-analysis and the ACR and EULAR guidelines, and taking into account the limited availability of studies and data about anti-IL-1 in osteoarthritis treatment, more high-quality RCTs on this subject are needed to verify if this is a proper method of KOA treatment and if it can be added into standardized guidelines. Here, IL1B is linked to osteoarthritis.