It has been observed that PBM can reduce inflammatory cell migration [48,59], as well as TNF-α [55,56,57,59], COX-2 [58], IL-1β [53,56,58,59,60], and IL-6 [56,57,58,59,60] cytokine levels, which have been shown to contribute to a general decrease in the inflammatory response in animal models of many conditions, including tendonitis [48,58], osteoarthritis [59], and acute inflammation [55,56,60]. The gene discussed is TNF; the disease is osteoarthritis.