Active immune surveillance of herpesviridae infection (in particular varicella zoster virus chickenpox etiological factor, followed by neurons for long-term residence and reactivation, with the clinical symptoms of herpes zoster) is carried out by macrophages producing IFNs, TNF-α, and IL-6, and lymphocytes producing IFN-γ [38,39,40]. This evidence concerns the gene IL6 and Herpesviridae infectious disease.