IL1B and acne: Zhu X. et al. (2020) proved that the flavonoid wogonin present in Scutellaria baicalensis Georgi extracts exerts better anti-acne effects than its glycoside wogonoside (wogonin 7-glucuronide) (Figure 6) in inhibiting the up-regulation of IL-1β and IL-8 levels caused by C. acnes through inactivation of the MAPK and NF-κB signaling pathways.