HK2 and neoplasm: Brassinin also exhibited anti-Warburg effects by suppressing glycolysis-related proteins like pyruvate kinase isoenzyme M2 (PKM2), glucose transporter 1 (Glut1), hexokinase 2 (HK2), and lactate dehydrogenase (LDH) in PC-3 cells, indicating an impact on the tumor’s energy metabolism.