STAT3 and neoplasm: Astragaloside IV, a natural saponin from Astragalus membranaceus, has been shown to inhibit M2 polarization through signaling pathways such as TLR4/NF-κB/STAT3, thereby regulating the tumor microenvironment and inhibiting Huh-7 nude mouse hepatocellular carcinoma tumor proliferation, invasion and migration in vivo [23].