The sebogenesis-related factors, including sterol regulatory element-binding protein 1 (SREBP-1), 11β-hydroxysteroid dehydrogenase (11β-HSD), peroxisome proliferator-activated receptor (PPAR)-γ and glucocorticoid receptor (GR), also named as NR3C1 (nuclear receptor subfamily 3, group C, member 1), in the P. acnes-induced acne-like mouse ear skin lesions were determined by immunohistochemical staining (Figure 5A,C) and ELISA assays (Figure 5E–H). Here, PPARG is linked to acne.