The results suggest that tumor necrosis factor (TNF), interleukin-1β (IL-1β), interleukin-6 (IL-6), Estrogen Receptor alpha (ESR1), peroxisome proliferator-activated receptor gamma (PPAR-γ), Nuclear factor kappa B subunit 1 (NFκB1), signal transducer and activator of transcription 3 (STAT3) and Toll-like receptor 4 (TLR4) may be the most critical targets of Glycyrrhetinic acid against acne vulgaris (Figure 1D). The gene discussed is TLR4; the disease is acne.