Complexes cis,trans,cis-[Pt(NH3)2(OH)(cin)Cl2] 64 and cis,trans,cis-[Pt(NH3)2(cin)2Cl2] 65 exhibit enhanced antiproliferative activity in both monolayer and 3D spheroid assays in cervical adenocarcinoma (HeLa), colon carcinoma (HCT116, both p53-positive and p53-non-expressing), breast cancer (invasive ductal carcinoma) (MDA-MB-231), adenocarcinoma (MCF-7), and muscle rhabdomyosarcoma. Here, TP53 is linked to breast carcinoma.