BTK and mantle cell lymphoma: Specifically, 5-aminopyrazoles (5APs) have been deeply studied for their anti-inflammatory and anticancer activity [17,18], providing useful ligands for receptors or enzymes, as p38 MAPK [19,20,21,22], COX [23], carbonic anhydrase [24], and other different targets involved in cancer progression [25,26], as demonstrated by the recent approval of 5AP Pirtobrutinib, a reversible BTK inhibitor, clinically used for the treatment of mantle cell lymphoma (MCL) [27,28,29,30,31,32,33].