LRP1 and colorectal cancer: Qin X. et al. [34] found that LRP and LRM anthocyanidins alone (incubated for 48 h) failed to prevent tumor cell proliferation, but once applied together, significant anti-tumor activity was observed, resulting from a combination of LRP and LRM anthocyanidins, this inhibition of cancer cell proliferation occurs by blocking the G0-G1 cell cycle and inducing apoptosis of human colorectal cancer LoVo cells via a reactive oxygen species (ROS)-dependent pathway.