Apoptosis analysis in the IRAK1/4 dual inhibitor-treated murine monocyte/macrophage leukemia cell line RAW 264.7 and human acute monocytic leukemia cell line THP-1 showed higher induction of apoptosis compared to when treated with the IRAK1 selective inhibitor JH-X-119-01. The gene discussed is IRAK1; the disease is acute monocytic leukemia.