Using relevant enzymatic inhibition assays to confirm traditional medicinal uses, such as hyperglycemia control and the treatment of mental disorders, labdanum resin, mainly that extracted by Andalusian process, is worth to be further study as a medicinal product or a source of pharmaceuticals ingredients with anti-diabetic and neuroprotective activities, as the labdane-type diterpenoids revealed potential as α-amylase inhibitors, and the overall Andalusian labdanum resin revealed potential as a source of acetylcholinesterase inhibitors. This evidence concerns the gene ACHE and psychiatric disorder.