The kallikrein proteomics analysis of the diabetic macular edema [74] and antibody-array interaction mapping method to detect the activation of the plasma PK [75], and hydrolysis of PK to kallikrein when bound to HK on cells to liberate BK [76], have demonstrated their crucial role involved in disease-related signaling networks. The gene discussed is KNG1; the disease is diabetic macular edema.