While chronic elevation of Ang II induces hypertension that is accompanied by enhanced thrombosis in arterioles through the angiotensin type 2 receptor-dependent pathway [77], treatment with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists appears to affect the balance between the RAS and KKS axis, regulating not only blood pressure but also thrombosis [78]. Here, ACE is linked to hypertensive disorder.