Due to their ability to regulate various vasoactive peptides that help to control water and electrolytes, cause smooth muscles in the heart and the blood vessels to relax, and delay thrombus formation through the activation of the plasma kallikrein–kinin system (KKS) and regulation of angiotensin molecules, PRCP-dependent pathways appear to play a remarkable role in vascular physiology and in the development of cardiovascular disease. Here, KLK4 is linked to cardiovascular disorder.