ACHE and Alzheimer disease: Previous studies demonstrated that the ethanolic extract of DE functioned as an anti-AD agent by quenching oxidative stress, inhibiting acetylcholine (AChE)-degrading enzymes (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) in vitro, and inhibiting BACE-1 activities, resulting in the reduction of Aβ peptides in the brain and improved locomotor functions in Drosophila models of AD [16].