In contrast, the inhibitory effects of BACE-1 and the reduction in amyloid peptides Aβ1-40 and Aβ1-42 in neuronal cells were observed exclusively with quercetin [43], suggesting that while kaempferol was abundant in the optimized DE extract, quercetin may possess bioactive anti-AD properties in vivo. Here, BACE1 is linked to Alzheimer disease.