DKK3 and osteosarcoma: The Wnt/β-catenin/LEF1 signaling pathway has also been shown to be involved in human osteosarcoma cells and tissues via RT-qPCR, where it was indicated that LEF1 translation via degradation of DKK3 was mediated through miR-214-3p, and that cantharidin could be a prospective candidate for osteosarcoma by targeting the pathways involved [96].