Patients with a very early stage of colon cancer (Tis-T1) had also a statistically significant difference regarding total MV counts, TF-positive MVs, EMVs, combined EMV/TF MVs, MUC-1-positive MVs, and MUC-1/TF combined MVs (all p < 0.001) (Figure 2C,D). This evidence concerns the gene MUC1 and malignant colon neoplasm.