According to our study, patients with early-stage colorectal cancer (T1-T2) as well as patients with very early-stage colorectal cancer (Tis-T1) had higher total numbers of MVs, EMVs, MUC-1-positive MVs, TF-positive MVs, EMV/TF combined MVs, and MUC-1/TF combined MVs compared to controls. This evidence concerns the gene MUC1 and colorectal cancer.