PI3K/AKT/mTOR and hypoxia/HIF1α signaling, in collaboration with other signaling pathways, induces the expression of EMT-TF genes (i.e., SNAIL, ZEB1/2, and TWIST1/2) and activates EMT in cancers, including PCa [40,41]. The gene discussed is TWIST1; the disease is posterior cortical atrophy.