Among the identified reciprocal miRNA/mRNA pairings involved in aggressive PCa, miR-99b-5p/MTOR (upregulated/downregulated) pairing has been revealed as a central miRNA/mRNA pairing coordinating PI3K/AKT/mTOR signaling with HIF-1α and VEGF pathways [33,34]. Here, HIF1A is linked to posterior cortical atrophy.