Furthermore, our studies have shown that miR-99b-5p simultaneously targets and inhibits the expression of MTOR, AR, and SMARCD1 (encoding SMARCD1, an AR coregulator), consequently blocking the translocation of the mTOR/AR/SMARCD1 complex from the cytoplasm to the nucleus, inhibiting the expression of mTOR/AR target genes, reversing metabolic rewiring, and sensitizing AA PCa and CRPC to Enz [34]. Here, AR is linked to posterior cortical atrophy.