To test this hypothesis, we performed a series of functional and biochemical experiments to examine whether transfection/overexpression of miR-99b-5p mimic could inhibit the expression of EMT-TF (Snail) and mesenchymal markers (N-cadherin and Vimentin) and restore the expression of epithelial marker (E-cadherin), ultimately inhibiting the metastatic capacities of AA PCa and CRPC cells. The gene discussed is CDH1; the disease is posterior cortical atrophy.