Due to the central/unique role of the reciprocal miR-99b-5p/MTOR pairing (downregulated/upregulated in AA PCa) in coordinating PI3K/AKT/mTOR, HIF1α, and AR signaling [31,33,34], we hypothesized that the miR-99b-5p/mTOR/AR/SMARCD1 signaling axis may play a critical functional role in regulating EMT-mediated metastasis in AA PCa and CRPC. This evidence concerns the gene HIF1A and posterior cortical atrophy.