The expression of VEGF-B, and its receptor VEGFR-1, was explored across a panel of eighteen normal human tissues and fifteen common tumor types (breast intraductal carcinoma, breast intralobular carcinoma, mesothelioma, melanoma, colorectal adenocarcinoma, renal cell carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, hepatocellular carcinoma, pancreatic adenocarcinoma, prostate, ovary and uterine adenocarcinoma, bladder transitional cell carcinoma, and brain glioblastoma multiforme) from 12 to 15 different human donors using tissue microarrays (TMAs). This evidence concerns the gene FLT1 and hereditary clear cell renal cell carcinoma.