Our presented and previously reported genetic and epigenetic investigations on KEAP1/NRF2 and NOTCH genes in a collection of neuroendocrine cell lines confirmed that KEAP1 and NFE2L2 genes mutations only marginally affect the SCLC histology and are typically related to non-small cell lung cancer (NSCLC) [11,30,39]. This evidence concerns the gene KEAP1 and small cell lung carcinoma.