IFNG and small cell lung carcinoma: The latter mainly refers to an inflamed state with low expression levels of the previous transcription factors but high expression levels of IFN-γ activation and immune checkpoint molecule expression [36,37], also being correlated to better overall survival (OS) in subgroup analysis of IMpower133 and CASPIAN trials investigating atezolizumab or durvalumab, respectively, plus chemotherapy in SCLC patients with extensive disease stage [7,38].