KEAP1 and cancer: The KEAP1 mRNA was significantly downregulated in the four cancer cell lines H1184, H69V, H209, and H1963, having a mutation (H1184, p.Gly364Cys) or a hypermethylation in the KEAP1 promoter gene (H69V, H209, H1963) or an LOH at the KEAP1 locus (Hcc33) in comparison with the N417, GLC1, and GLC2 cell lines (p = 0.0007, t-test), showing no genetic or DNA methylation alterations in KEAP1 or NFE2L2 genes (Figure 1).