More specifically, if an aberrant crosstalk between NRF2 and NOTCH exists in SCLC, it should be modulated by genetic lesions and aberrant DNA methylation in key genes of their pathways, such as KEAP1, which should establish a synergic and critical effect on tumorigenesis and progression of the disease [22,23,27]. Here, NFE2L2 is linked to small cell lung carcinoma.