KEAP1 and small cell lung carcinoma: Similarly to the KEAP1-silencing effect of SiRNA, the effects of aberrant promoter DNA methylation of the KEAP1 gene on its transcript levels were previously reported in the H69V SCLC cell line using 5-AZA-CdR (p < 0.05, t-test); a progressive increase in KEAP1 transcript abundance was observed after 48 h (p < 0.05) and 72 h (p < 0.01) and was shown to correlate with decreased KEAP1 promoter methylation at 48 h (p < 0.001) and at 72 h (p < 0.01) [32].