Our presented and previously reported genetic and epigenetic investigations on KEAP1/NRF2 and NOTCH genes in a collection of neuroendocrine cell lines confirmed that KEAP1 and NFE2L2 genes mutations only marginally affect the SCLC histology and are typically related to non-small cell lung cancer (NSCLC) [11,30,39]. The gene discussed is NFE2L2; the disease is non-small cell lung carcinoma.