PBRM1 and cancer: We identified 579 core members of this module, containing a strong enrichment for chromatin modifying factors including many which are recurrently mutated in cancer, such as ARID1A, ARID2, PBRM1, SUZ12, and TET2 [34] (Figure 5C), as well as other well-established components of the SWI/SNF, NuRD, TFII, and TFIII complexes, and more.