Second, we observed that our goblet module #123 and ERK module #84 genes were almost entirely higher in iCMS3—consistent with their high levels of KRAS/BRAF mutations—while our MSI-low modules #26 and #47 (Figure 4A) genes were almost entirely higher in iCMS2 (Figure 7D), suggesting that these four modules accurately captured tumor-intrinsic signatures. Here, MAPK1 is linked to neoplasm.