RAC1 and non-small cell lung carcinoma: In HCC, NSC23766 can block the invasion and migration by inhibiting the CAMSAP2-dependent Rac1/JNK pathway, or the cysteine-rich domains-1 (LMCD1)-Rac1 pathway [132], while in NSCLC cells, it can regulate NF-kB activity, cell proliferation and cell migration [120].