While the ultra high-risk cases showed a generally cold TME, with few tumor-infiltrating lymphocytes (TILs) and downregulation of major histocompatibility complex (MHC) class II, the MYCN-non-amplified high-risk groups were characterized by a hot TME, exhibiting increased infiltration by NK and CD8+ T-cells and expression of immune checkpoint proteins. The gene discussed is MYCN; the disease is neoplasm.