The combined application of CK7 and CD117 is a reliable first-level panel to discriminate lesions in the spectrum of eosinophilic/oncocytic tumors, with RO being CK7neg/CD117pos, ChrRCC CK7pos/CD117pos, the EVT CK7neg/CD117pos, the LOT CK7pos/CD117neg, and ESC-RCC CK7neg/CD117neg [59] (see Table 3). The gene discussed is KIT; the disease is renal cell carcinoma.