PD-L1 high-expressing tumors show hypermethylated genes and promoters with strong oncogenic effects (SNORD114-14, DCAF4L2, S100A7L2, and SOD1P3) and hypermethylated genes and promoters with tumor suppressor effects (CELF2-AS1 and LINCMD1). This evidence concerns the gene LINCMD1 and neoplasm.