LINC00528 (Long Intergenic Non-Protein Coding RNA 528) (average methylation 73%, p = 0.001) was identified as a long non-coding RNA found in computational analyses to be associated with neutrophils, lymphocytes, and macrophages involved in the immune reaction of the tumor microenvironment and strongly correlated with immunotherapy prognosis in lung cancer. This evidence concerns the gene LINC00528 and neoplasm.