Thus, the tissues start to become less sensitive to insulin, leading to an increase in the postprandial glucose concentration (ideal values for women with GDM are fasting glucose ≤5–5.3 mmol/L (90–95 mg/dL) and either one-hour post-meal ≤ 7.8 mmol/L (140 mg/dL) or 2 h post-meal ≤ 6.7 mmol/L (120 mg/dL)) [19,20]. Here, INS is linked to gestational diabetes.