The intense molecular communication between TANs, cancer-associated fibroblasts (CAFs), and neoplastic cells is characterized by the production of cardiotrophin-like cytokine factor 1 by CAFs, which determines the production of CXCL5, TGF-β, and IL-6 and the involvement of the neutrophils, with N2 polarization [70]. The gene discussed is CXCL5; the disease is cancer.