CD4 and neoplasm: The role of CD4+ T cells can also be inferred from translational studies, such as the one conducted by Dhanasekaran R. et al. [119], where an increase in CD4+ lymphocytes in the tumor microenvironment was observed following treatment with antisense oligonucleotides (ASOs) to decrease the expression of the oncogene MYC in murine models of HCC.