The role of CD4+ T cells can also be inferred from translational studies, such as the one conducted by Dhanasekaran R. et al. [119], where an increase in CD4+ lymphocytes in the tumor microenvironment was observed following treatment with antisense oligonucleotides (ASOs) to decrease the expression of the oncogene MYC in murine models of HCC. This evidence concerns the gene MYC and hepatocellular carcinoma.