The NADPH oxidase 2 (NOX2) expressed by myeloid cells (including mature monocytic AML cells) generates highly immunosuppressive reactive oxygen species (ROS) that inhibit the expression of NCRs, including NKp46 and NKp30, and also trigger the apoptosis of NK cells to impede their cytolytic activity against leukemic cells [16,17,18,19,20]. The gene discussed is NCR3; the disease is acute myeloid leukemia.