CYBB and acute myeloid leukemia: The NADPH oxidase 2 (NOX2) expressed by myeloid cells (including mature monocytic AML cells) generates highly immunosuppressive reactive oxygen species (ROS) that inhibit the expression of NCRs, including NKp46 and NKp30, and also trigger the apoptosis of NK cells to impede their cytolytic activity against leukemic cells [16,17,18,19,20].