Cell line differentiation was induced by DHODH inhibitors through inhibition of the downstream enzyme ‘Orotydilate decarboxylase’ and subsequent blockade of uridine monophosphate (UMP) synthesis, independent from the expression of Dihydroorotate which hence does not represent a biomarker of leukemogenesis, as 2-hydroxyglutarate (2HG) is in patients with IDH mutated leukemias. Here, DHODH is linked to leukemia.