CD274 and large cell carcinoma: Remarkably, moderate–high PD-L1 expression (scores 2, 3) was observed to correlate with dedifferentiation, as high percentages of PD-L1 expression characterized the overwhelming majority of pleomorphic LUACs and LSCCs, as well as the histologically dedifferentiated pleomorphic tumors (spindle and large cell carcinomas) along with no/low β-catenin membranous expression.