In particular, 100% of the KPL (1/1) cohort, almost half of the KL and KC cohorts (44% (7/16) and 43% (9/21), respectively), one-third of the KP and KRAS mutant LKB1-intact cohorts (29% (4/14) and (6/21), respectively), and one-quarter of the K cohort (25% (1/4)) yielded metastasis in both regional and distant mediastinal (LN1 and LN2) lymph nodes. The gene discussed is STK11; the disease is keratoconus.