In vitro studies revealed that LKB1 inactivation increased cell motility and invasiveness [16,33] and favored epithelial–mesenchymal transition in lung cancer cells through upregulation of Zinc-finger E-box-binding homeobox factor 1 (ZEB1), a transcriptional repressor for E-cadherin and an EMT inducer, thus enhancing metastatic potential [34,35]. The gene discussed is STK11; the disease is lung cancer.