RHO and gastric cancer: Based on the above research results, we hypothesize that one of the mechanisms by which PGC inhibits the migration and invasion of GC cells may be by promoting the downregulation of the IQGAP1 protein via interacting with IQGAP1 and thereby inhibiting the expression of Rho protein in the Rho-GTPase pathway, with ultimate inhibitory effects on GC cell migration and invasion.