Results of this study suggested that PGC overexpression can downregulate IQGAP1 protein expression and significantly inhibit migration of GC cells, and that effect can be restored by IQGAP1 overexpression, which suggested that the regulation of IQGAP1 by PGC plays an important role in inhibiting the migration and invasion of GC cells. The gene discussed is IQGAP1; the disease is gastric cancer.