CAFs produced and secerned several cytokines and chemokines, including IL-1α, IL-1β, IL-6, IL-8, and CXCL10, but also overexpressed programmed death ligand-1 and/or -2 (PD-L1/PD-L2), confirming that CAFs promotes invasion of melanoma with the release of different molecules, which may act both alone and in synergic combination [97]. Here, CXCL8 is linked to melanoma.