Overexpression of isoforms VEGF121 and VEGF165 induced tumor growth in human melanoma xenografts, but overexpression of VEGF189 had no such effect [26], while VEGF-A-expressing tumor-infiltrating inflammatory cells are linked to the up-regulation of VEGF-A expression in the setting of metastatic melanoma [27]. Here, VEGFA is linked to metastatic melanoma.