Both Ang-1 and Ang-2 are expressed in melanoma tumors; however, the balance between Ang-1 and Ang-2 expression is altered in melanoma, favoring angiogenesis, and high levels of Ang-2 relative to Ang-1 are associated with increased tumor vascularity, tumor progression, and poor prognosis [61,62]. The gene discussed is ANGPT1; the disease is neoplasm.