To investigate the mechanism underlying the promoting effect of PH on the development of krasG12V-induced zebrafish HCC, we performed RNA-Seq with the kras+ and WT male zebrafish livers on Day 5 after Dox induction and determined the differential expressed genes (DEGs) of the kras+ livers versus the WT livers (Figure 4A). The gene discussed is KRAS; the disease is hepatocellular carcinoma.