To model KRAS mutation-induced HCC with zebrafish, Tg(fabp10a:rtTA2s-M2; TRE2:EGFP-krasG12V) (gz32Tg) (abbreviated as kras+), which has the liver-specific expression of krasG12V under the control of the Tet-on system, has been generated by our lab previously [21]. This evidence concerns the gene USP6 and hepatocellular carcinoma.