The results showed that immunoglobulin (IgA, IgM, and IgG) and antioxidant–related enzymes (MDA, T–AOC, CAT, GSH–Px, and T–SOD) in the serum of crossbred offspring (CAH and CDH) lambs did not differ from those of H lambs (p > 0.05). The gene discussed is GSS; the disease is congenital adrenal hyperplasia.