MAPK8 and cancer: Another study demonstrated that a glycosylated form of Apigenin, namely Vitexin, attenuated the protein level of HIF1α in rat pheochromocytoma (PC12) cells under hypoxic conditions by partly altering the Jun N-terminal kinases (JNK) pathway, thus leading to a reduction in transcription of the VEGF gene, followed by reduced cancer invasion in vitro.