The results demonstrated that Apigenin, via IL-6 inhibition, decreased the cellular expression of Snail and N-cadherin; on the other hand, the reduced expression of IL-6, phosphorylated Signal Transducer and Activator of Transcription-3 (pSTAT3), phosphorylated extracellular signal-related kinase (pERK), and phosphorylated Akt (pAkt) inhibited tumor growth and invasiveness in xenograft mice [48]. This evidence concerns the gene STAT3 and neoplasm.