Increasing doses of Apigenin inhibited cell viability, migration, and invasion of human colon cancer cells (HCT-116 and LOVO), combined with a significant inversion in E-cadherin and vimentin expression; at the same time, the flavone, by inhibiting NF-κB, Snail, Ki-67, NF-κB, and p65 inhibitor of NF-κB kinase (IKK), suppressed tumorigenicity of HCT-116 cells in nude mice xenografts [39]. This evidence concerns the gene NFKB1 and malignant colon neoplasm.