GLI1 and ovarian carcinoma: Indeed, in a paper by Tang et al. (2015), it was shown that Apigenin (in a dose-dependent manner) inhibited the catalytic domain of CK2 (i.e., CK2α) and downregulated GLI Family Zinc Finger 1 (Gli1) expression, affecting the stemness of human ovarian cancer in vitro (SKOV3 cell line) and impeding the self-renewal capacity as well as the propensity to aggregate in spheroids [76].