TP53 and neoplasm: More specifically, in this tumor context, Apigenin disturbed the HIF-1α/VEGF axis by perturbing phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB or Akt)/ribosomal protein S6 kinase beta-1 (p70S6K1) and E3 ligase human double minute 2 (HDM2)/p53 signaling pathways [29].