Further studies showed that cancer cell cycle arrest at the G2/M phase through the inhibition of cyclin B-associated cdc2 occurred in many types of cancer cell lines treated with Apigenin, including skin cancer keratinocytes (two murine skin cell lines, C50 and 308) [92], oral cancer cells (squamous carcinoma cell) [93], melanoma cells [94], mouse keratinocytes [95], prostate cancer cells [96], and colon cancer cells [97]. This evidence concerns the gene CDK1 and cancer.