HIF1A and neoplasm: Similarly, Liu et al. showed that Apigenin (in a dose/time-dependent manner) significantly reduced HIF-1α expression and VEGF transcriptional activity in human lung cancer in vitro (A549 cell line) through the inactivation of Akt and p70S6K1 signals; in parallel, the suppression of angiogenesis activity was followed by inhibition of tumor expansion in murine xenografts [30].