TP53 and colonic neoplasm: Apigenin induced G2/M phase arrest of the cell cycle in ovarian cancer cells (SKOV-3), as evidenced by flow cytometry [88], and in colon cancer cells (HCT116 line) by increasing the expression of the G2/M cell cycle negative regulators p53 and p21 [89]; in papillary thyroid carcinoma (BCPAP line), Apigenin inhibited growth by decreasing the expression of the G2/M cell cycle positive regulator cdc25C (cell division cycle 25C) [90].