Similar functional effects of Apigenin were observed by using an additional human breast cancer cell model (MDA-MB-468, TNBC, highly metastatic) whose stemness features were abolished by the inhibition of sirtuin-3 (SIRT3) and sirtuin-6 (SIRT6) protein levels, as supported by in silico analyses [70]. The gene discussed is SIRT3; the disease is breast cancer.