It is important to note that Apigenin has been shown to trigger the extrinsic apoptosis pathway by directly binding and inhibiting adenine nucleotide translocase-2 (ANT2), thereby indirectly enhancing apo2 ligand (Apo2L)/TRAIL-induced apoptosis [139], or by stimulating the upregulation of death receptors 4 and 5 (DR4 and DR5) in a p53-dependent manner, thereby sensitizing NSCLC cells to TRAIL-induced apoptosis [140]. The gene discussed is TNFRSF10A; the disease is non-small cell lung carcinoma.