PIK3CA and overgrowth syndrome: Tenorio syndrome, a rare overgrowth syndrome evolving with MC and/or large forehead, neurodevelopmental disease, and systemic inflammation, including Sjogren’s syndrome features, is due to RNF125 mutations encoding an E3 ubiquitin resulting in dysregulation of several cellular pathways, including that of PI3K–AKT and IFN, respectively [70].