Moreover, the CML+apoA-I+CIGB-258 group showed the smallest IL-6-stained area (photo e1 and e2), ~6.3%, which was 73% lower (p < 0.001) than that of the CML+PBS group, indicating the strongest synergistic anti-inflammatory activity through the co-presence of apoA-I and CIGB-258. Here, IL6 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.