The CML-induced neutrophil infiltration was effectively countered by the injection of apoA-I, CIGB-258 and apoA-I+CIGB-258, evident in a significant 2.8-fold, 2.7-fold and 8.8-fold reduced neutrophil count in the respective groups, as compared to the CML-injected group. This evidence concerns the gene APOA1 and chronic myelogenous leukemia, BCR-ABL1 positive.