CHI3L1 and Alzheimer disease: In our previous studies, we found that the CHI3L1 inhibitor, 2-({3-[2-(1-cyclohexen-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanamide (K284-6111), alleviated memory dysfunction and neuroinflammation in β-amyloid (Aβ-induced) and transgenic (Tg2576) AD mouse model [11,27].