In our previous study, we presented that CHI3L1 may be related to PTX3 by means of the web-based GWAS analysis and demonstrated the relationship between CHI3L1 and PTX3 and the relationship between PTX3 and neuroinflammation using a transgenic AD mouse model and Aβ-induced BV-2 cells (Figure 6A) [11]. Here, PTX3 is linked to Alzheimer disease.