In a recent study, Yanan Deng reported that inhibition of the Notch pathway using DAPT alleviated autism-like behaviors and reduced NRG1 and phosphorylated ErbB4 levels, suggesting the involvement of the Notch1/Hes1 pathway in regulating the NRG1/ErbB4 pathway in autism [27]. This evidence concerns the gene HES1 and autism.