With their precision engineering, nanoparticles can target tumor-supporting cancer-associated fibroblasts (CAFs) and distinct markers on PDAC cells, such as epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), integrins, hyaluronan, transferrin, etc. This targeted approach significantly improves the specificity and effectiveness of treatments [10,17,18,19,20]. Here, EGFR is linked to neoplasm.