Well-documented scientific evidence is reported for some of them for their involvement in cancer (NORAD, SNHG6, NFS1, SLMO2-ATP5E, RAB5IF, EDEM2, VAPB, RBM39, TPD522, CPN1, SRSF6), and they gave us good confidence in the validity of the model adopted, suggesting the necessity of further analysis to investigate their involvement in the mechanisms supporting CRC pathogenesis. Here, EDEM2 is linked to cancer.