The NLRP3 inflammasome plays a pivotal role in mediating inflammatory responses, as it is known that it is a key regulator of the immune response and is associated with various high-risk reproductive disorders like endometriosis and polycystic ovarian syndrome, as well as those related to pregnancy like gestational diabetes, preeclampsia, preterm birth, and recurrent spontaneous abortion [22]. Here, NLRP3 is linked to gestational diabetes.